2h9m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2h9m.gif|left|200px]]<br /><applet load="2h9m" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2h9m.gif|left|200px]]
-
caption="2h9m, resolution 1.90&Aring;" />
+
 
-
'''WDR5 in complex with unmodified H3K4 peptide'''<br />
+
{{Structure
 +
|PDB= 2h9m |SIZE=350|CAPTION= <scene name='initialview01'>2h9m</scene>, resolution 1.90&Aring;
 +
|SITE=
 +
|LIGAND=
 +
|ACTIVITY=
 +
|GENE= WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
}}
 +
 
 +
'''WDR5 in complex with unmodified H3K4 peptide'''
 +
 
==Overview==
==Overview==
Line 10: Line 19:
==About this Structure==
==About this Structure==
-
2H9M is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9M OCA].
+
2H9M is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9M OCA].
==Reference==
==Reference==
-
Structural basis for molecular recognition and presentation of histone H3 by WDR5., Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J, EMBO J. 2006 Sep 20;25(18):4245-52. Epub 2006 Aug 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16946699 16946699]
+
Structural basis for molecular recognition and presentation of histone H3 by WDR5., Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J, EMBO J. 2006 Sep 20;25(18):4245-52. Epub 2006 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16946699 16946699]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
Line 30: Line 39:
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
[[Category: sgc]]
[[Category: sgc]]
-
[[Category: structural genomics]]
+
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: structural genomics consortium]]
[[Category: wdr5]]
[[Category: wdr5]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:39:35 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:14:20 2008''

Revision as of 15:14, 20 March 2008

Image:2h9m.gif


PDB ID 2h9m

Drag the structure with the mouse to rotate
, resolution 1.90Å
Gene: WDR5, BIG3 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



WDR5 in complex with unmodified H3K4 peptide


Contents

Overview

Histone methylation at specific lysine residues brings about various downstream events that are mediated by different effector proteins. The WD40 domain of WDR5 represents a new class of histone methyl-lysine recognition domains that is important for recruiting H3K4 methyltransferases to K4-dimethylated histone H3 tail as well as for global and gene-specific K4 trimethylation. Here we report the crystal structures of full-length WDR5, WDR5Delta23 and its complexes with unmodified, mono-, di- and trimethylated histone H3K4 peptides. The structures reveal that WDR5 is able to bind all of these histone H3 peptides, but only H3K4me2 peptide forms extra interactions with WDR5 by use of both water-mediated hydrogen bonding and the altered hydrophilicity of the modified lysine 4. We propose a mechanism for the involvement of WDR5 in binding and presenting histone H3K4 for further methylation as a component of MLL complexes.

Disease

Known disease associated with this structure: Asphyxiating thoracic dystrophy 2 OMIM:[611177]

About this Structure

2H9M is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for molecular recognition and presentation of histone H3 by WDR5., Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J, EMBO J. 2006 Sep 20;25(18):4245-52. Epub 2006 Aug 31. PMID:16946699

Page seeded by OCA on Thu Mar 20 17:14:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2h9m"
Personal tools