4nwr

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'''Unreleased structure'''
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==Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28==
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<StructureSection load='4nwr' size='340' side='right' caption='[[4nwr]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nwr]] is a 96 chain structure. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw6 1vw6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NWR FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nwn|4nwn]], [[4nwo|4nwo]], [[4nwp|4nwp]], [[4nwq|4nwq]], [[1vw5|1vw5]], [[1vw6|1vw6]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nwr RCSB], [http://www.ebi.ac.uk/pdbsum/4nwr PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The self-assembly of proteins into highly ordered nanoscale architectures is a hallmark of biological systems. The sophisticated functions of these molecular machines have inspired the development of methods to engineer self-assembling protein nanostructures; however, the design of multi-component protein nanomaterials with high accuracy remains an outstanding challenge. Here we report a computational method for designing protein nanomaterials in which multiple copies of two distinct subunits co-assemble into a specific architecture. We use the method to design five 24-subunit cage-like protein nanomaterials in two distinct symmetric architectures and experimentally demonstrate that their structures are in close agreement with the computational design models. The accuracy of the method and the number and variety of two-component materials that it makes accessible suggest a route to the construction of functional protein nanomaterials tailored to specific applications.
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The entry 4nwr is ON HOLD until May 28 2015
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Accurate design of co-assembling multi-component protein nanomaterials.,King NP, Bale JB, Sheffler W, McNamara DE, Gonen S, Gonen T, Yeates TO, Baker D Nature. 2014 Jun 5;510(7503):103-8. doi: 10.1038/nature13404. Epub 2014 May 25. PMID:24870237<ref>PMID:24870237</ref>
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Authors: McNamara, D.E., King, N.P., Bale, J.B., Sheffler, W., Baker, D., Yeates, T.O.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Baker, D]]
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[[Category: Bale, J B]]
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[[Category: King, N P]]
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[[Category: McNamara, D E]]
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[[Category: Sheffler, W]]
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[[Category: Yeates, T O]]
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[[Category: Computational biology]]
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[[Category: Computational design]]
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[[Category: Designed protein cage]]
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[[Category: Integron]]
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[[Category: Macrophage migration-inhibitory factor]]
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[[Category: Multimerization]]
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[[Category: Nanomaterial]]
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[[Category: Nanostructure]]
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[[Category: Protein binding]]
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[[Category: Protein engineering]]
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[[Category: Self-assembling]]
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[[Category: Tetrahedron]]
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[[Category: Two-component]]

Revision as of 09:18, 5 January 2015

Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28

4nwr, resolution 3.50Å

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