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4mxa

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<StructureSection load='4mxa' size='340' side='right' caption='[[4mxa]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4mxa' size='340' side='right' caption='[[4mxa]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neocl Neocl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXA OCA]. <br>
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<table><tr><td colspan='2'>[[4mxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neocl Neocl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MXA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BK7:3-(6-ETHOXYNAPHTHALEN-2-YL)-1-(PIPERIDIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>BK7</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BK7:3-(6-ETHOXYNAPHTHALEN-2-YL)-1-(PIPERIDIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>BK7</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m97|4m97]], [[3sx9|3sx9]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m97|4m97]], [[3sx9|3sx9]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDPK1, NCLIV_011980, XP_003880764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=572307 NEOCL])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDPK1, NCLIV_011980, XP_003880764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=572307 NEOCL])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mxa RCSB], [http://www.ebi.ac.uk/pdbsum/4mxa PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mxa RCSB], [http://www.ebi.ac.uk/pdbsum/4mxa PDBsum]</span></td></tr>
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<table>
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</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.,Ojo KK, Reid MC, Kallur Siddaramaiah L, Muller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A PLoS One. 2014 Mar 28;9(3):e92929. doi: 10.1371/journal.pone.0092929. eCollection, 2014. PMID:24681759<ref>PMID:24681759</ref>
Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.,Ojo KK, Reid MC, Kallur Siddaramaiah L, Muller J, Winzer P, Zhang Z, Keyloun KR, Vidadala RS, Merritt EA, Hol WG, Maly DJ, Fan E, Van Voorhis WC, Hemphill A PLoS One. 2014 Mar 28;9(3):e92929. doi: 10.1371/journal.pone.0092929. eCollection, 2014. PMID:24681759<ref>PMID:24681759</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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[[Category: Calcium/calmodulin-dependent protein kinase]]
[[Category: Calcium/calmodulin-dependent protein kinase]]
[[Category: Neocl]]
[[Category: Neocl]]
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[[Category: Merritt, E A.]]
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[[Category: Merritt, E A]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Calcium-binding]]
[[Category: Calcium-binding]]

Revision as of 09:45, 5 January 2015

CDPK1 from Neospora caninum in complex with inhibitor RM-1-132

4mxa, resolution 3.00Å

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