4mvn

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mvn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mvn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVN FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I1S:[(1S)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-PHENYLETHYL]PHOSPHONIC+ACID'>I1S</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I1S:[(1S)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-PHENYLETHYL]PHOSPHONIC+ACID'>I1S</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ufa|3ufa]], [[3w7s|3w7s]], [[2w7u|2w7u]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ufa|3ufa]], [[3w7s|3w7s]], [[2w7u|2w7u]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPLA, SAOUHSC_01942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93061 STAA8])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPLA, SAOUHSC_01942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93061 STAA8])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mvn RCSB], [http://www.ebi.ac.uk/pdbsum/4mvn PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mvn RCSB], [http://www.ebi.ac.uk/pdbsum/4mvn PDBsum]</span></td></tr>
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<table>
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</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.,Burchacka E, Zdzalik M, Niemczyk JS, Pustelny K, Popowicz G, Wladyka B, Dubin A, Potempa J, Sienczyk M, Dubin G, Oleksyszyn J Protein Sci. 2013 Dec 4. doi: 10.1002/pro.2403. PMID:24375505<ref>PMID:24375505</ref>
Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.,Burchacka E, Zdzalik M, Niemczyk JS, Pustelny K, Popowicz G, Wladyka B, Dubin A, Potempa J, Sienczyk M, Dubin G, Oleksyszyn J Protein Sci. 2013 Dec 4. doi: 10.1002/pro.2403. PMID:24375505<ref>PMID:24375505</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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</StructureSection>
</StructureSection>
[[Category: Staa8]]
[[Category: Staa8]]
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[[Category: Burchacka, E.]]
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[[Category: Burchacka, E]]
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[[Category: Dubin, A.]]
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[[Category: Dubin, A]]
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[[Category: Dubin, G.]]
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[[Category: Dubin, G]]
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[[Category: Niemczyk, J S.]]
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[[Category: Niemczyk, J S]]
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[[Category: Oleksyszyn, J.]]
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[[Category: Oleksyszyn, J]]
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[[Category: Popowicz, G M.]]
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[[Category: Popowicz, G M]]
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[[Category: Potempa, J.]]
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[[Category: Potempa, J]]
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[[Category: Pustelny, K.]]
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[[Category: Pustelny, K]]
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[[Category: Sienczyk, M.]]
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[[Category: Sienczyk, M]]
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[[Category: Wladyka, B.]]
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[[Category: Wladyka, B]]
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[[Category: Zdzalik, M.]]
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[[Category: Zdzalik, M]]
[[Category: Chymotrypsin-like fold]]
[[Category: Chymotrypsin-like fold]]
[[Category: Extracellular staphylococcal protease]]
[[Category: Extracellular staphylococcal protease]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Serine endopeptidase]]
[[Category: Serine endopeptidase]]

Revision as of 09:45, 5 January 2015

Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor

4mvn, resolution 1.70Å

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