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4q0n

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<StructureSection load='4q0n' size='340' side='right' caption='[[4q0n]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
<StructureSection load='4q0n' size='340' side='right' caption='[[4q0n]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4q0n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0N OCA]. <br>
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<table><tr><td colspan='2'>[[4q0n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q0N FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XD:(2E)-1-(2-HYDROXYPHENYL)-3-(2,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDIN-6-YL)PROP-2-EN-1-ONE'>2XD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XD:(2E)-1-(2-HYDROXYPHENYL)-3-(2,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDIN-6-YL)PROP-2-EN-1-ONE'>2XD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q0o|4q0o]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q0o|4q0o]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0n RCSB], [http://www.ebi.ac.uk/pdbsum/4q0n PDBsum]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0n RCSB], [http://www.ebi.ac.uk/pdbsum/4q0n PDBsum]</span></td></tr>
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</table>
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<table>
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== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Chaikuad, A.]]
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[[Category: Chaikuad, A]]
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[[Category: Delft, F von.]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Fedorov, O.]]
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[[Category: Fedorov, O]]
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[[Category: Felletar, I.]]
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[[Category: Felletar, I]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos, P]]
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[[Category: Knapp, S.]]
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[[Category: Knapp, S]]
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[[Category: Martin, S.]]
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[[Category: Martin, S]]
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[[Category: Monteiro, O.]]
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[[Category: Monteiro, O]]
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[[Category: Picaud, S.]]
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[[Category: Picaud, S]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Yue, W.]]
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[[Category: Yue, W]]
[[Category: Baf180]]
[[Category: Baf180]]
[[Category: Brg1-associated factor 180]]
[[Category: Brg1-associated factor 180]]
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[[Category: Polybromo-1d]]
[[Category: Polybromo-1d]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
 
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]

Revision as of 09:48, 5 January 2015

Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand

4q0n, resolution 1.78Å

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