4jqh
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain== | |
| - | + | <StructureSection load='4jqh' size='340' side='right' caption='[[4jqh]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | {{ | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[4jqh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_7120 Anabaena 7120]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JQH FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MF:4-{[(4-CARBOXYBUTYL)(2-{2-[(4-PHENOXYBIPHENYL-4-YL)METHOXY]PHENYL}ETHYL)AMINO]METHYL}BENZOIC+ACID'>1MF</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l6j|3l6j]], [[4iae|4iae]], [[4iah|4iah]], [[4iam|4iam]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">alr2278 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=103690 Anabaena 7120])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_cyclase Guanylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.2 4.6.1.2] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jqh RCSB], [http://www.ebi.ac.uk/pdbsum/4jqh PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Recently, the structure of BAY 58-2667 bound to the Nostoc sp. H-NOX domain was published. On the basis of this structural information, we designed BAY 58-2667 derivatives and tested their effects on soluble guanylyl cyclase (sGC) activity. Derivative 20 activated sGC 4.8-fold more than BAY 58-2667. Co-crystallization of 20 with the Ns H-NOX domain revealed that the increased conformational distortion at the C-terminal region of alphaF helix containing 110-114 residues contributes to the higher activation triggered by 20. | ||
| - | + | Insights into Soluble Guanylyl Cyclase Activation Derived from Improved Heme-Mimetics.,von Wantoch Rekowski M, Kumar V, Zhou Z, Moschner J, Marazioti A, Bantzi M, Spyroulias GA, van den Akker F, Giannis A, Papapetropoulos A J Med Chem. 2013 Oct 24. PMID:24090476<ref>PMID:24090476</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Anabaena 7120]] | [[Category: Anabaena 7120]] | ||
[[Category: Guanylate cyclase]] | [[Category: Guanylate cyclase]] | ||
| - | [[Category: Akker, F van den | + | [[Category: Akker, F van den]] |
| - | [[Category: Kumar, V | + | [[Category: Kumar, V]] |
[[Category: Analogue of bay58-2667]] | [[Category: Analogue of bay58-2667]] | ||
[[Category: Guanylyl cyclase]] | [[Category: Guanylyl cyclase]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Revision as of 12:24, 5 January 2015
Crystal structure of a new sGC activator (analogue of BAY 58-2667) bound to nostoc H-NOX domain
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