4qgk
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qgk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QGK FirstGlance]. <br> | <table><tr><td colspan='2'>[[4qgk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QGK FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(+)) Aldehyde dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.3 1.2.1.3] </span></td></tr> | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(+)) Aldehyde dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.3 1.2.1.3] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qgk RCSB], [http://www.ebi.ac.uk/pdbsum/4qgk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qgk RCSB], [http://www.ebi.ac.uk/pdbsum/4qgk PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/AL3A2_HUMAN AL3A2_HUMAN]] Sjogren-Larsson syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:8528251</ref> <ref>PMID:9254849</ref> <ref>PMID:9829906</ref> <ref>PMID:10577908</ref> <ref>PMID:10792573</ref> | [[http://www.uniprot.org/uniprot/AL3A2_HUMAN AL3A2_HUMAN]] Sjogren-Larsson syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:8528251</ref> <ref>PMID:9254849</ref> <ref>PMID:9829906</ref> <ref>PMID:10577908</ref> <ref>PMID:10792573</ref> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/AL3A2_HUMAN AL3A2_HUMAN]] Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.<ref>PMID:22633490</ref> | [[http://www.uniprot.org/uniprot/AL3A2_HUMAN AL3A2_HUMAN]] Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.<ref>PMID:22633490</ref> | ||
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| + | ==See Also== | ||
| + | *[[Aldehyde dehydrogenase|Aldehyde dehydrogenase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Keller, M | + | [[Category: Keller, M]] |
| - | [[Category: Marquez, J A | + | [[Category: Marquez, J A]] |
| - | [[Category: Zander, U | + | [[Category: Zander, U]] |
[[Category: Aldehyde dehydrogenase]] | [[Category: Aldehyde dehydrogenase]] | ||
[[Category: Fatty aldehyde dehydrogenase]] | [[Category: Fatty aldehyde dehydrogenase]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Sjogren larsson syndrome]] | [[Category: Sjogren larsson syndrome]] | ||
Revision as of 13:01, 5 January 2015
Structure of the Human Sjogren Larsson Syndrome enzyme fatty aldehyde dehydrogenase (FALDH)
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