2hmt

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[[Image:2hmt.jpg|left|200px]]<br /><applet load="2hmt" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2hmt.jpg|left|200px]]
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caption="2hmt, resolution 2.200&Aring;" />
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'''Diamond-shaped octameric ring structure of an RCK domain with NADH bound'''<br />
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{{Structure
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|PDB= 2hmt |SIZE=350|CAPTION= <scene name='initialview01'>2hmt</scene>, resolution 2.200&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE'>NAI</scene>
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|ACTIVITY=
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|GENE= yuaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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}}
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'''Diamond-shaped octameric ring structure of an RCK domain with NADH bound'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2HMT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=NAI:'>NAI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HMT OCA].
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2HMT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HMT OCA].
==Reference==
==Reference==
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The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring., Albright RA, Ibar JL, Kim CU, Gruner SM, Morais-Cabral JH, Cell. 2006 Sep 22;126(6):1147-59. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16990138 16990138]
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The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring., Albright RA, Ibar JL, Kim CU, Gruner SM, Morais-Cabral JH, Cell. 2006 Sep 22;126(6):1147-59. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16990138 16990138]
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: symporter]]
[[Category: symporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:43:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:18:56 2008''

Revision as of 15:18, 20 March 2008

Image:2hmt.jpg


PDB ID 2hmt

Drag the structure with the mouse to rotate
, resolution 2.200Å
Ligands:
Gene: yuaA (Bacillus subtilis)
Coordinates: save as pdb, mmCIF, xml



Diamond-shaped octameric ring structure of an RCK domain with NADH bound


Overview

The KtrAB ion transporter is a complex of the KtrB membrane protein and KtrA, an RCK domain. RCK domains regulate eukaryotic and prokaryotic membrane proteins involved in K(+) transport. Conflicting functional models have proposed two different oligomeric arrangements for RCK domains, tetramer versus octamer. Our results for the KtrAB RCK domain clearly show an octamer in solution and in the crystal. We determined the structure of this protein in three different octameric ring conformations that resemble the RCK-domain octamer observed in the MthK potassium channel but show striking differences in size and symmetry. We present experimental evidence for the association between one RCK octameric ring and two KtrB membrane proteins. These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation and show that the RCK-domain octameric ring model is generally applicable to other ion-transport systems.

About this Structure

2HMT is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring., Albright RA, Ibar JL, Kim CU, Gruner SM, Morais-Cabral JH, Cell. 2006 Sep 22;126(6):1147-59. PMID:16990138

Page seeded by OCA on Thu Mar 20 17:18:56 2008

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