2hth

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[[Image:2hth.jpg|left|200px]]<br /><applet load="2hth" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2hth.jpg|left|200px]]
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caption="2hth, resolution 2.70&Aring;" />
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'''Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain'''<br />
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{{Structure
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|PDB= 2hth |SIZE=350|CAPTION= <scene name='initialview01'>2hth</scene>, resolution 2.70&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= RPS27A, UBA52, UBB, UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2HTH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTH OCA].
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2HTH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTH OCA].
==Reference==
==Reference==
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Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain., Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI, Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17057716 17057716]
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Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain., Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI, Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17057716 17057716]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: viral budding]]
[[Category: viral budding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:45:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:21:21 2008''

Revision as of 15:21, 20 March 2008

Image:2hth.jpg


PDB ID 2hth

Drag the structure with the mouse to rotate
, resolution 2.70Å
Gene: RPS27A, UBA52, UBB, UBC (Homo sapiens), VPS36, C13orf9, EAP45 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain


Contents

Overview

The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.

Disease

Known disease associated with this structure: Cleft palate, isolated OMIM:[191339]

About this Structure

2HTH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain., Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI, Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22. PMID:17057716

Page seeded by OCA on Thu Mar 20 17:21:21 2008

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OCA

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