2huy

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[[Image:2huy.gif|left|200px]]<br /><applet load="2huy" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2huy.gif|left|200px]]
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caption="2huy, resolution 1.700&Aring;" />
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'''X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.'''<br />
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{{Structure
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|PDB= 2huy |SIZE=350|CAPTION= <scene name='initialview01'>2huy</scene>, resolution 1.700&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=YVN:N-({(1R,2R,3S)-2-[(METHYLAMINO)CARBONYL]-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-L-VALYL-L-ASPARTAMIDE'>YVN</scene> and <scene name='pdbligand=FMT:FORMIC ACID'>FMT</scene>
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|ACTIVITY=
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|GENE= GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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2HUY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=YVN:'>YVN</scene> and <scene name='pdbligand=FMT:'>FMT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUY OCA].
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2HUY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUY OCA].
==Reference==
==Reference==
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Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions., Benfield AP, Teresk MG, Plake HR, DeLorbe JE, Millspaugh LE, Martin SF, Angew Chem Int Ed Engl. 2006 Oct 20;45(41):6830-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17001728 17001728]
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Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions., Benfield AP, Teresk MG, Plake HR, DeLorbe JE, Millspaugh LE, Martin SF, Angew Chem Int Ed Engl. 2006 Oct 20;45(41):6830-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17001728 17001728]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ligand preorganization]]
[[Category: ligand preorganization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:46:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:21:54 2008''

Revision as of 15:22, 20 March 2008

Image:2huy.gif


PDB ID 2huy

Drag the structure with the mouse to rotate
, resolution 1.700Å
Ligands: and
Gene: GRB2, ASH (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.


Disease

Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[100790], Haddad syndrome OMIM:[100790]

About this Structure

2HUY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions., Benfield AP, Teresk MG, Plake HR, DeLorbe JE, Millspaugh LE, Martin SF, Angew Chem Int Ed Engl. 2006 Oct 20;45(41):6830-5. PMID:17001728

Page seeded by OCA on Thu Mar 20 17:21:54 2008

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OCA

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