This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1l5s
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1l5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L5S FirstGlance]. <br> | <table><tr><td colspan='2'>[[1l5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L5S FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=700:[5-CHLORO-1H-INDOL-2-CARBONYL-PHENYLALANINYL]-AZETIDINE-3-CARBOXYLIC+ACID'>700</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NBG:1-N-ACETYL-BETA-D-GLUCOSAMINE'>NBG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=URC:URIC+ACID'>URC</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=700:[5-CHLORO-1H-INDOL-2-CARBONYL-PHENYLALANINYL]-AZETIDINE-3-CARBOXYLIC+ACID'>700</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NBG:1-N-ACETYL-BETA-D-GLUCOSAMINE'>NBG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=URC:URIC+ACID'>URC</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l5q|1l5q]], [[1l5r|1l5r]], [[1l7x|1l7x]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l5q|1l5q]], [[1l5r|1l5r]], [[1l7x|1l7x]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l5s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l5s RCSB], [http://www.ebi.ac.uk/pdbsum/1l5s PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l5s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l5s RCSB], [http://www.ebi.ac.uk/pdbsum/1l5s PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/PYGL_HUMAN PYGL_HUMAN]] Defects in PYGL are the cause of glycogen storage disease type 6 (GSD6) [MIM:[http://omim.org/entry/232700 232700]]. A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected.<ref>PMID:9529348</ref> | [[http://www.uniprot.org/uniprot/PYGL_HUMAN PYGL_HUMAN]] Defects in PYGL are the cause of glycogen storage disease type 6 (GSD6) [MIM:[http://omim.org/entry/232700 232700]]. A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected.<ref>PMID:9529348</ref> | ||
| Line 39: | Line 39: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphorylase]] | [[Category: Phosphorylase]] | ||
| - | [[Category: Carty, M D | + | [[Category: Carty, M D]] |
| - | [[Category: Culp, J | + | [[Category: Culp, J]] |
| - | [[Category: Danley, D E | + | [[Category: Danley, D E]] |
| - | [[Category: Day, Y S.N | + | [[Category: Day, Y S.N]] |
| - | [[Category: Ekstrom, J L | + | [[Category: Ekstrom, J L]] |
| - | [[Category: Fletterick, R J | + | [[Category: Fletterick, R J]] |
| - | [[Category: Gibbs, E M | + | [[Category: Gibbs, E M]] |
| - | [[Category: Hoover, D J | + | [[Category: Hoover, D J]] |
| - | [[Category: Myszka, D G | + | [[Category: Myszka, D G]] |
| - | [[Category: Pauly, T A | + | [[Category: Pauly, T A]] |
| - | [[Category: Rath, V L | + | [[Category: Rath, V L]] |
| - | [[Category: Soeller, W C | + | [[Category: Soeller, W C]] |
| - | [[Category: Treadway, J L | + | [[Category: Treadway, J L]] |
| - | + | ||
[[Category: Purine site]] | [[Category: Purine site]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 16:26, 5 January 2015
Human liver glycogen phosphorylase complexed with uric acid, N-Acetyl-beta-D-glucopyranosylamine, and CP-403,700
| |||||||||||
Categories: Homo sapiens | Phosphorylase | Carty, M D | Culp, J | Danley, D E | Day, Y S.N | Ekstrom, J L | Fletterick, R J | Gibbs, E M | Hoover, D J | Myszka, D G | Pauly, T A | Rath, V L | Soeller, W C | Treadway, J L | Purine site | Transferase
