2hxw

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[[Image:2hxw.jpg|left|200px]]<br /><applet load="2hxw" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2hxw.jpg|left|200px]]
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caption="2hxw, resolution 1.60&Aring;" />
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'''Crystal Structure of Peb3 from Campylobacter jejuni'''<br />
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{{Structure
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|PDB= 2hxw |SIZE=350|CAPTION= <scene name='initialview01'>2hxw</scene>, resolution 1.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=FLC:CITRATE ANION'>FLC</scene>
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|ACTIVITY=
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|GENE= peb3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197 Campylobacter jejuni])
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}}
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'''Crystal Structure of Peb3 from Campylobacter jejuni'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2HXW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni] with <scene name='pdbligand=FLC:'>FLC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXW OCA].
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2HXW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXW OCA].
==Reference==
==Reference==
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Structural context for protein N-glycosylation in bacteria: The structure of PEB3, an adhesin from Campylobacter jejuni., Rangarajan ES, Bhatia S, Watson DC, Munger C, Cygler M, Matte A, Young NM, Protein Sci. 2007 May;16(5):990-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17456748 17456748]
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Structural context for protein N-glycosylation in bacteria: The structure of PEB3, an adhesin from Campylobacter jejuni., Rangarajan ES, Bhatia S, Watson DC, Munger C, Cygler M, Matte A, Young NM, Protein Sci. 2007 May;16(5):990-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17456748 17456748]
[[Category: Campylobacter jejuni]]
[[Category: Campylobacter jejuni]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: peb3]]
[[Category: peb3]]
[[Category: periplasmic binding protein]]
[[Category: periplasmic binding protein]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:46:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:23:01 2008''

Revision as of 15:23, 20 March 2008

Image:2hxw.jpg


PDB ID 2hxw

Drag the structure with the mouse to rotate
, resolution 1.60Å
Ligands:
Gene: peb3 (Campylobacter jejuni)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Peb3 from Campylobacter jejuni


Overview

Campylobacter jejuni is unusual among bacteria in possessing a eukaryotic-like system for N-linked protein glycosylation at Asn residues in sequons of the type Asp/Glu-Xaa-Asn-Xaa-Ser/Thr. However, little is known about the structural context of the glycosylated sequons, limiting the design of novel recombinant glycoproteins. To obtain more information on sequon structure, we have determined the crystal structure of the PEB3 (Cj0289c) dimer. PEB3 has the class II periplasmic-binding protein fold, with each monomer having two domains with a ligand-binding site containing citrate located between them, and overall resembles molybdate- and sulfate-binding proteins. The sequon around Asn90 is located within a surface-exposed loop joining two structural elements. The three key residues are well exposed on the surface; hence, they may be accessible to the PglB oligosaccharyltransferase in the folded state.

About this Structure

2HXW is a Single protein structure of sequence from Campylobacter jejuni. Full crystallographic information is available from OCA.

Reference

Structural context for protein N-glycosylation in bacteria: The structure of PEB3, an adhesin from Campylobacter jejuni., Rangarajan ES, Bhatia S, Watson DC, Munger C, Cygler M, Matte A, Young NM, Protein Sci. 2007 May;16(5):990-5. PMID:17456748

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