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1kv6
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KV6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KV6 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ere|1ere]], [[3erd|3erd]], [[1k4w|1k4w]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ere|1ere]], [[3erd|3erd]], [[1k4w|1k4w]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children. | [[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bourguet, W | + | [[Category: Bourguet, W]] |
| - | [[Category: Dorsselaer, A van | + | [[Category: Dorsselaer, A van]] |
| - | [[Category: Greschik, H | + | [[Category: Greschik, H]] |
| - | [[Category: Moras, D | + | [[Category: Moras, D]] |
| - | [[Category: Renaud, J P | + | [[Category: Renaud, J P]] |
| - | [[Category: SPINE, Structural Proteomics in Europe | + | [[Category: SPINE, Structural Proteomics in Europe]] |
| - | [[Category: Sanglier, S | + | [[Category: Sanglier, S]] |
| - | [[Category: Wurtz, J M | + | [[Category: Wurtz, J M]] |
[[Category: Gene regulation]] | [[Category: Gene regulation]] | ||
[[Category: Spine]] | [[Category: Spine]] | ||
Revision as of 17:05, 5 January 2015
X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation
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Categories: Homo sapiens | Bourguet, W | Dorsselaer, A van | Greschik, H | Moras, D | Renaud, J P | SPINE, Structural Proteomics in Europe | Sanglier, S | Wurtz, J M | Gene regulation | Spine | Structural genomic | Structural proteomics in europe | Transcriptionally active conformation in absence of ligand
