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2i1p
From Proteopedia
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| - | [[Image:2i1p.jpg|left|200px]] | + | [[Image:2i1p.jpg|left|200px]] |
| - | + | ||
| - | '''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin''' | + | {{Structure |
| + | |PDB= 2i1p |SIZE=350|CAPTION= <scene name='initialview01'>2i1p</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2I1P is a [ | + | 2I1P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:[http:// | + | Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17245526 17245526] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: low density lipoprotein receptor]] | [[Category: low density lipoprotein receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:24:22 2008'' |
Revision as of 15:24, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin
Overview
Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence.
About this Structure
2I1P is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:17245526
Page seeded by OCA on Thu Mar 20 17:24:22 2008
