2i30

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2i30.gif|left|200px]]<br /><applet load="2i30" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2i30.gif|left|200px]]
-
caption="2i30, resolution 2.900&Aring;" />
+
 
-
'''Human serum albumin complexed with myristate and salicylic acid'''<br />
+
{{Structure
 +
|PDB= 2i30 |SIZE=350|CAPTION= <scene name='initialview01'>2i30</scene>, resolution 2.900&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene> and <scene name='pdbligand=MYR:MYRISTIC ACID'>MYR</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''Human serum albumin complexed with myristate and salicylic acid'''
 +
 
==Overview==
==Overview==
Line 10: Line 19:
==About this Structure==
==About this Structure==
-
2I30 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SAL:'>SAL</scene> and <scene name='pdbligand=MYR:'>MYR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I30 OCA].
+
2I30 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I30 OCA].
==Reference==
==Reference==
-
Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin., Yang F, Bian C, Zhu L, Zhao G, Huang Z, Huang M, J Struct Biol. 2007 Feb;157(2):348-55. Epub 2006 Sep 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17067818 17067818]
+
Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin., Yang F, Bian C, Zhu L, Zhao G, Huang Z, Huang M, J Struct Biol. 2007 Feb;157(2):348-55. Epub 2006 Sep 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17067818 17067818]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 28: Line 37:
[[Category: plasma protein]]
[[Category: plasma protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:48:31 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:24:48 2008''

Revision as of 15:24, 20 March 2008

Image:2i30.gif


PDB ID 2i30

Drag the structure with the mouse to rotate
, resolution 2.900Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Human serum albumin complexed with myristate and salicylic acid


Contents

Overview

Human serum albumin (HSA) is the most abundant plasma protein in the human body with a plasma concentration of 0.6mM. HSA plays an important role in drug transport and metabolism. Enzymatic activity of HSA on different substrates or drugs has been studied and documented. The structural mechanism of this activity, however, is unknown. In this study, we have determined the crystal structures of HSA-myristate in a complex of aspirin and of salicylic acid, respectively. The crystal structure of HSA-myristate-aspirin illustrates that aspirin transfers acetyl group to Lys199 and is hydrolyzed into salicylic acid by HSA. The hydrolysis product, salicylic acid, remains bound to HSA at a similar location, but it shows a very different orientation when compared with the salicylic acid in the HSA-myristate-salicylic acid ternary complex. These results not only provide the structural evidence of esterase activity of HSA, and demonstrate the conformational plasticity of HSA on drug binding, but also may provide structural information for the modulation of HSA-drug interaction by computational approach based on HSA-drug structure.

Disease

Known diseases associated with this structure: Analbuminemia OMIM:[103600], Dysalbuminemic hyperthyroxinemia OMIM:[103600], Dysalbuminemic hyperzincemia OMIM:[103600]

About this Structure

2I30 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin., Yang F, Bian C, Zhu L, Zhao G, Huang Z, Huang M, J Struct Biol. 2007 Feb;157(2):348-55. Epub 2006 Sep 9. PMID:17067818

Page seeded by OCA on Thu Mar 20 17:24:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i30"
Personal tools