1q6k

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1q6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q6K FirstGlance]. <br>
<table><tr><td colspan='2'>[[1q6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q6K FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCO:TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE'>TCO</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCO:TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE'>TCO</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK OR CTSO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK OR CTSO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q6k RCSB], [http://www.ebi.ac.uk/pdbsum/1q6k PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q6k RCSB], [http://www.ebi.ac.uk/pdbsum/1q6k PDBsum]</span></td></tr>
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<table>
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</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
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[[Category: Cathepsin K]]
[[Category: Cathepsin K]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Catalano, J G.]]
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[[Category: Catalano, J G]]
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[[Category: Deaton, D N.]]
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[[Category: Deaton, D N]]
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[[Category: Furfine, E S.]]
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[[Category: Furfine, E S]]
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[[Category: Hassell, A M.]]
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[[Category: Hassell, A M]]
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[[Category: McFadyen, R B.]]
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[[Category: McFadyen, R B]]
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[[Category: Miller, A B.]]
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[[Category: Miller, A B]]
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[[Category: Miller, L R.]]
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[[Category: Miller, L R]]
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[[Category: Shewchuk, L M.]]
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[[Category: Shewchuk, L M]]
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[[Category: Willard, D H.]]
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[[Category: Willard, D H]]
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[[Category: Wright, L L.]]
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[[Category: Wright, L L]]
[[Category: Cathepsin k]]
[[Category: Cathepsin k]]
[[Category: Catk]]
[[Category: Catk]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 07:03, 6 January 2015

Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate

1q6k, resolution 2.10Å

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