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2icw
From Proteopedia
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| - | [[Image:2icw.gif|left|200px]] | + | [[Image:2icw.gif|left|200px]] |
| - | + | ||
| - | '''Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule''' | + | {{Structure |
| + | |PDB= 2icw |SIZE=350|CAPTION= <scene name='initialview01'>2icw</scene>, resolution 2.410Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= HLA-DRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), HLA-DRB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2ICW is a [ | + | 2ICW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Mycoplasma_arthritidis Mycoplasma arthritidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICW OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC., Wang L, Zhao Y, Li Z, Guo Y, Jones LL, Kranz DM, Mourad W, Li H, Nat Struct Mol Biol. 2007 Feb;14(2):169-71. Epub 2007 Jan 14. PMID:[http:// | + | Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC., Wang L, Zhao Y, Li Z, Guo Y, Jones LL, Kranz DM, Mourad W, Li H, Nat Struct Mol Biol. 2007 Feb;14(2):169-71. Epub 2007 Jan 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17220897 17220897] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| Line 23: | Line 32: | ||
[[Category: tcr]] | [[Category: tcr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:27:59 2008'' |
Revision as of 15:28, 20 March 2008
| |||||||
| , resolution 2.410Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | HLA-DRA (Homo sapiens), HLA-DRB1 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule
Overview
'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.
About this Structure
2ICW is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Mycoplasma arthritidis. Full crystallographic information is available from OCA.
Reference
Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC., Wang L, Zhao Y, Li Z, Guo Y, Jones LL, Kranz DM, Mourad W, Li H, Nat Struct Mol Biol. 2007 Feb;14(2):169-71. Epub 2007 Jan 14. PMID:17220897
Page seeded by OCA on Thu Mar 20 17:27:59 2008
