1r8u
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1r8u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R8U FirstGlance]. <br> | <table><tr><td colspan='2'>[[1r8u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R8U FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CITED2, MRG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CITED2, MRG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r8u RCSB], [http://www.ebi.ac.uk/pdbsum/1r8u PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r8u RCSB], [http://www.ebi.ac.uk/pdbsum/1r8u PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/CITE2_HUMAN CITE2_HUMAN]] Defects in CITED2 are a cause of ventricular septal defect type 2 (VSD2) [MIM:[http://omim.org/entry/614431 614431]]. VSD2 is a common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death.<ref>PMID:16287139</ref> Defects in CITED2 are a cause of atrial septal defect type 8 (ASD8) [MIM:[http://omim.org/entry/614433 614433]]. ASD8 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.<ref>PMID:16287139</ref> | [[http://www.uniprot.org/uniprot/CITE2_HUMAN CITE2_HUMAN]] Defects in CITED2 are a cause of ventricular septal defect type 2 (VSD2) [MIM:[http://omim.org/entry/614431 614431]]. VSD2 is a common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death.<ref>PMID:16287139</ref> Defects in CITED2 are a cause of atrial septal defect type 8 (ASD8) [MIM:[http://omim.org/entry/614433 614433]]. ASD8 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.<ref>PMID:16287139</ref> | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Dyson, H J | + | [[Category: Dyson, H J]] |
| - | [[Category: Guzman, R N.De | + | [[Category: Guzman, R N.De]] |
| - | [[Category: Martinez-Yamout, M | + | [[Category: Martinez-Yamout, M]] |
| - | [[Category: Wright, P E | + | [[Category: Wright, P E]] |
[[Category: Protein-protein complex]] | [[Category: Protein-protein complex]] | ||
[[Category: Taz zinc finger]] | [[Category: Taz zinc finger]] | ||
[[Category: Transcription-transcription activator complex]] | [[Category: Transcription-transcription activator complex]] | ||
[[Category: Zinc-binding motif]] | [[Category: Zinc-binding motif]] | ||
Revision as of 08:18, 6 January 2015
NMR structure of CBP TAZ1/CITED2 complex
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