1xkk
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xkk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The June 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Epidermal Growth Factor Receptor'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_6 10.2210/rcsb_pdb/mom_2010_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XKK FirstGlance]. <br> | <table><tr><td colspan='2'>[[1xkk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The June 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Epidermal Growth Factor Receptor'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_6 10.2210/rcsb_pdb/mom_2010_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XKK FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMM:N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE'>FMM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMM:N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE'>FMM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EGFR, ERBB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EGFR, ERBB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xkk RCSB], [http://www.ebi.ac.uk/pdbsum/1xkk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xkk RCSB], [http://www.ebi.ac.uk/pdbsum/1xkk PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN]] Defects in EGFR are associated with lung cancer (LNCR) [MIM:[http://omim.org/entry/211980 211980]]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. | [[http://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN]] Defects in EGFR are associated with lung cancer (LNCR) [MIM:[http://omim.org/entry/211980 211980]]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. | ||
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[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
| - | [[Category: Alligood, K J | + | [[Category: Alligood, K J]] |
| - | [[Category: Dickerson, S H | + | [[Category: Dickerson, S H]] |
| - | [[Category: Ellis, B | + | [[Category: Ellis, B]] |
| - | [[Category: Gilmer, T M | + | [[Category: Gilmer, T M]] |
| - | [[Category: Hassell, A | + | [[Category: Hassell, A]] |
| - | [[Category: Horne, E | + | [[Category: Horne, E]] |
| - | [[Category: Lackey, K | + | [[Category: Lackey, K]] |
| - | [[Category: McDonald, O B | + | [[Category: McDonald, O B]] |
| - | [[Category: Pennisi, C | + | [[Category: Pennisi, C]] |
| - | [[Category: Rusnak, D W | + | [[Category: Rusnak, D W]] |
| - | [[Category: Shewchuk, L M | + | [[Category: Shewchuk, L M]] |
| - | [[Category: Truesdale, A T | + | [[Category: Truesdale, A T]] |
| - | [[Category: Wood, E R | + | [[Category: Wood, E R]] |
| - | [[Category: Yuan, D | + | [[Category: Yuan, D]] |
[[Category: Egfr]] | [[Category: Egfr]] | ||
[[Category: Epidermal growth factor receptor]] | [[Category: Epidermal growth factor receptor]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
| - | [[Category: Transferase]] | ||
Revision as of 13:14, 6 January 2015
EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
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Categories: Epidermal Growth Factor Receptor | Homo sapiens | RCSB PDB Molecule of the Month | Transferase | Alligood, K J | Dickerson, S H | Ellis, B | Gilmer, T M | Hassell, A | Horne, E | Lackey, K | McDonald, O B | Pennisi, C | Rusnak, D W | Shewchuk, L M | Truesdale, A T | Wood, E R | Yuan, D | Egfr | Epidermal growth factor receptor | Kinase
