1ik3
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1IK3 is a | + | 1IK3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Glycine_max Glycine max] with FE, 13S, 13R, 9OH and 11O as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] Structure known Active Site: FE3. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IK3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: purple lipoxygenase]] | [[Category: purple lipoxygenase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:56:00 2007'' |
Revision as of 11:50, 5 November 2007
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LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID
Overview
Polyunsaturated fatty acid metabolism is governed primarily by two, enzymes, prostaglandin H synthase and lipoxygenase. The crystal structure, of the metastable product-oxidized purple form of soybean lipoxygenase-3, was determined at 2.0 A resolution. The data reveal that the chromophore, corresponds to an iron-peroxide complex, a potential intermediate in the, catalyzed reaction. A significant alteration of the iron site accompanies, the formation of the complex. The structure, the first for a fatty, acid-lipoxygenase complex, also reveals an unexpected mode of binding, and, identifies amino acid residues that may play significant roles in, catalysis, regio- and stereoselectivity.
About this Structure
1IK3 is a Single protein structure of sequence from Glycine max with FE, 13S, 13R, 9OH and 11O as ligands. Active as Lipoxygenase, with EC number 1.13.11.12 Structure known Active Site: FE3. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of a purple lipoxygenase., Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr, J Am Chem Soc. 2001 Nov 7;123(44):10814-20. PMID:11686682
Page seeded by OCA on Mon Nov 5 13:56:00 2007
Categories: Glycine max | Lipoxygenase | Single protein | Jr., M.O.Funk. | Skrzypczak-Jankun, E. | 11O | 13R | 13S | 9OH | FE | Fe(iii) complex | Interm | Oxidoreductase | Purple lipoxygenase
