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1xiu
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xiu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Biomphalaria_glabrata Biomphalaria glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XIU FirstGlance]. <br> | <table><tr><td colspan='2'>[[1xiu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Biomphalaria_glabrata Biomphalaria glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XIU FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fby|1fby]], [[1lbd|1lbd]], [[1g1u|1g1u]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fby|1fby]], [[1lbd|1lbd]], [[1g1u|1g1u]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6526 Biomphalaria glabrata])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RXR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6526 Biomphalaria glabrata])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xiu RCSB], [http://www.ebi.ac.uk/pdbsum/1xiu PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xiu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xiu RCSB], [http://www.ebi.ac.uk/pdbsum/1xiu PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children. | [[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children. | ||
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[[Category: Biomphalaria glabrata]] | [[Category: Biomphalaria glabrata]] | ||
[[Category: Histone acetyltransferase]] | [[Category: Histone acetyltransferase]] | ||
| - | [[Category: Borel, F | + | [[Category: Borel, F]] |
| - | [[Category: Ferrer, J L | + | [[Category: Ferrer, J L]] |
| - | [[Category: Fontecilla-Camps, J C | + | [[Category: Fontecilla-Camps, J C]] |
| - | [[Category: Groot, A De | + | [[Category: Groot, A De]] |
| - | [[Category: Juillan-Binard, C | + | [[Category: Juillan-Binard, C]] |
| - | [[Category: Laudet, V | + | [[Category: Laudet, V]] |
| - | [[Category: Pebay-Peroula, E | + | [[Category: Pebay-Peroula, E]] |
| - | [[Category: Rosny, E De | + | [[Category: Rosny, E De]] |
[[Category: Nuclear receptor]] | [[Category: Nuclear receptor]] | ||
[[Category: Protein-ligand complex]] | [[Category: Protein-ligand complex]] | ||
[[Category: Retinoid receptor]] | [[Category: Retinoid receptor]] | ||
[[Category: Transcription-transferase complex]] | [[Category: Transcription-transferase complex]] | ||
Revision as of 13:19, 6 January 2015
Crystal structure of the agonist-bound ligand-binding domain of Biomphalaria glabrata RXR
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