2iny
From Proteopedia
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| - | [[Image:2iny.jpg|left|200px]] | + | [[Image:2iny.jpg|left|200px]] |
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| - | '''Nanoporous Crystals of Chicken Embryo Lethal Orphan (CELO) Adenovirus Major Coat Protein, Hexon''' | + | {{Structure |
| + | |PDB= 2iny |SIZE=350|CAPTION= <scene name='initialview01'>2iny</scene>, resolution 3.900Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Nanoporous Crystals of Chicken Embryo Lethal Orphan (CELO) Adenovirus Major Coat Protein, Hexon''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2INY is a [ | + | 2INY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Fowl_adenovirus_1 Fowl adenovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2INY OCA]. |
==Reference== | ==Reference== | ||
| - | Nanoporous crystals of chicken embryo lethal orphan (CELO) adenovirus major coat protein, hexon., Xu L, Benson SD, Burnett RM, J Struct Biol. 2007 Feb;157(2):424-31. Epub 2006 Sep 14. PMID:[http:// | + | Nanoporous crystals of chicken embryo lethal orphan (CELO) adenovirus major coat protein, hexon., Xu L, Benson SD, Burnett RM, J Struct Biol. 2007 Feb;157(2):424-31. Epub 2006 Sep 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17071105 17071105] |
[[Category: Fowl adenovirus 1]] | [[Category: Fowl adenovirus 1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: viral jelly roll]] | [[Category: viral jelly roll]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:31:38 2008'' |
Revision as of 15:31, 20 March 2008
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| , resolution 3.900Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Nanoporous Crystals of Chicken Embryo Lethal Orphan (CELO) Adenovirus Major Coat Protein, Hexon
Overview
CELO (chicken embryo lethal orphan) virus is an avian adenovirus that is being developed as a gene transfer vector. Its trimeric major coat protein (942 residues, 106,709 Da) has 42% sequence identity to human adenovirus type 2 (AdH2) hexon and 45% to AdH5 hexon. For structural studies, the growth of CELO virus has been optimized, and its hexon purified and crystallized. The hexon crystals, the first non-human example, diffract to 3.9 A resolution. Molecular replacement using the AdH5 model was used to identify the location of the CELO hexon within the unit cell. There is one hexon monomer in the asymmetric unit of the trigonal space group P321 (a=b=157.8 A, c=114.2 A, gamma=120 degrees) and the solvent content is 67.8%. The hexons pack in a hexagonal honeycomb so that large approximately 100 A diameter channels run through the entire crystal. This remarkable property of the crystals lends itself to their exploitation as a nanomaterial. Structural studies on CELO will elucidate the differences between avian and human adenoviruses and contribute to a better understanding of adenoviruses with non-human hosts.
About this Structure
2INY is a Single protein structure of sequence from Fowl adenovirus 1. Full crystallographic information is available from OCA.
Reference
Nanoporous crystals of chicken embryo lethal orphan (CELO) adenovirus major coat protein, hexon., Xu L, Benson SD, Burnett RM, J Struct Biol. 2007 Feb;157(2):424-31. Epub 2006 Sep 14. PMID:17071105
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