1wmv
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br> | <table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WMV FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [http://www.ebi.ac.uk/pdbsum/1wmv PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> | [[http://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[http://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Booker, G W | + | [[Category: Booker, G W]] |
| - | [[Category: Colella, A | + | [[Category: Colella, A]] |
| - | [[Category: Kowalski, K | + | [[Category: Kowalski, K]] |
| - | [[Category: Merkel, A L | + | [[Category: Merkel, A L]] |
| - | [[Category: Richards, R I | + | [[Category: Richards, R I]] |
[[Category: All-beta]] | [[Category: All-beta]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Ww domain]] | [[Category: Ww domain]] | ||
Revision as of 14:10, 6 January 2015
Solution structure of the second WW domain of WWOX
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