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Odorant binding protein
From Proteopedia
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====Receptor activation i lepidoptora==== | ====Receptor activation i lepidoptora==== | ||
*'''The pH theory''' | *'''The pH theory''' | ||
| - | This theory is supported by several facts. First, it has been found that the BmPBP conformation is changing from its [["open form" (A)]] to the [["close form" (B)]] in a pH dependent manner | + | This theory is supported by several facts. First, it has been found that the BmPBP conformation is changing from its [["open form" (A)]] to the [["close form" (B)]] in a pH dependent manner [[wojtasek 1999]], and that the two conformations has different ligand affinities. |
second, the surface of the dendtrite is negatively charged [[Keil TA (1984) Surface coats of pore tubules and olfactory sensory dendrites of a silkmoth revealed by cationic markers. Tissue Cell 16(5):705–717]], | second, the surface of the dendtrite is negatively charged [[Keil TA (1984) Surface coats of pore tubules and olfactory sensory dendrites of a silkmoth revealed by cationic markers. Tissue Cell 16(5):705–717]], | ||
Leal WS, et al. (2005) Kinetics and molecular properties of pheromone binding and release. Proc Natl Acad Sci USA 102(15):5386–5391. | Leal WS, et al. (2005) Kinetics and molecular properties of pheromone binding and release. Proc Natl Acad Sci USA 102(15):5386–5391. | ||
Revision as of 13:21, 7 January 2015
Contents |
Introduction
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Protein conformations
Receptor activation i lepidoptora
- The pH theory
This theory is supported by several facts. First, it has been found that the BmPBP conformation is changing from its "open form" (A) to the "close form" (B) in a pH dependent manner wojtasek 1999, and that the two conformations has different ligand affinities. second, the surface of the dendtrite is negatively charged Keil TA (1984) Surface coats of pore tubules and olfactory sensory dendrites of a silkmoth revealed by cationic markers. Tissue Cell 16(5):705–717, Leal WS, et al. (2005) Kinetics and molecular properties of pheromone binding and release. Proc Natl Acad Sci USA 102(15):5386–5391.
- The other theory
See also
References
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