2ith
From Proteopedia
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| - | [[Image:2ith.jpg|left|200px]] | + | [[Image:2ith.jpg|left|200px]] |
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| - | '''NMR Structure of Haloferax volcanii DHFR''' | + | {{Structure |
| + | |PDB= 2ith |SIZE=350|CAPTION= <scene name='initialview01'>2ith</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] | ||
| + | |GENE= folA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2246 Haloferax volcanii]) | ||
| + | }} | ||
| + | |||
| + | '''NMR Structure of Haloferax volcanii DHFR''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2ITH is a [ | + | 2ITH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haloferax_volcanii Haloferax volcanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ITH OCA]. |
==Reference== | ==Reference== | ||
| - | Structure in an extreme environment: NMR at high salt., Binbuga B, Boroujerdi AF, Young JK, Protein Sci. 2007 Aug;16(8):1783-7. PMID:[http:// | + | Structure in an extreme environment: NMR at high salt., Binbuga B, Boroujerdi AF, Young JK, Protein Sci. 2007 Aug;16(8):1783-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17656587 17656587] |
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Haloferax volcanii]] | [[Category: Haloferax volcanii]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:33:08 2008'' |
Revision as of 15:33, 20 March 2008
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| Gene: | folA (Haloferax volcanii) | ||||||
| Activity: | Dihydrofolate reductase, with EC number 1.5.1.3 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structure of Haloferax volcanii DHFR
Overview
Proteins from halophiles have adapted to challenging environmental conditions and require salt for their structure and function. How halophilic proteins adapted to a hypersaline environment is still an intriguing question. It is important to mimic the physiological conditions of the archae extreme halophiles when characterizing their enzymes, including structural characterization. The NMR derived structure of Haloferax volcanii dihydrofolate reductase in 3.5 M NaCl is presented, and represents the first high salt structure calculated using NMR data. Structure calculations show that this protein has a solution structure which is similar to the previously determined crystal structure with a difference at the N terminus of beta3 and the type of beta-turn connection beta7 and beta8.
About this Structure
2ITH is a Single protein structure of sequence from Haloferax volcanii. Full crystallographic information is available from OCA.
Reference
Structure in an extreme environment: NMR at high salt., Binbuga B, Boroujerdi AF, Young JK, Protein Sci. 2007 Aug;16(8):1783-7. PMID:17656587
Page seeded by OCA on Thu Mar 20 17:33:08 2008
