2iu1

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[[Image:2iu1.gif|left|200px]]<br /><applet load="2iu1" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2iu1.gif|left|200px]]
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caption="2iu1, resolution 1.80&Aring;" />
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'''CRYSTAL STRUCTURE OF EIF5 C-TERMINAL DOMAIN'''<br />
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{{Structure
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|PDB= 2iu1 |SIZE=350|CAPTION= <scene name='initialview01'>2iu1</scene>, resolution 1.80&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF EIF5 C-TERMINAL DOMAIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2IU1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IU1 OCA].
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2IU1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IU1 OCA].
==Reference==
==Reference==
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The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5., Bieniossek C, Schutz P, Bumann M, Limacher A, Uson I, Baumann U, J Mol Biol. 2006 Jul 7;360(2):457-65. Epub 2006 May 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16781736 16781736]
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The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5., Bieniossek C, Schutz P, Bumann M, Limacher A, Uson I, Baumann U, J Mol Biol. 2006 Jul 7;360(2):457-65. Epub 2006 May 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16781736 16781736]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: translation inititation]]
[[Category: translation inititation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:55:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:33:20 2008''

Revision as of 15:33, 20 March 2008

Image:2iu1.gif


PDB ID 2iu1

Drag the structure with the mouse to rotate
, resolution 1.80Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF EIF5 C-TERMINAL DOMAIN


Overview

The carboxy-terminal domain (CTD) of eukaryotic initiation factor 5 (eIF5) plays a central role in the formation of the multifactor complex (MFC), an important intermediate for the 43 S pre-initiation complex assembly. The IF5-CTD interacts directly with the translation initiation factors eIF1, eIF2-beta, and eIF3c, thus forming together with eIF2 bound Met-tRNA(i)(Met) the MFC. In this work we present the high resolution crystal structure of eIF5-CTD. This domain of the protein is exclusively composed out of alpha-helices and is homologous to the carboxy-terminal domain of eIF2B-epsilon (eIF2Bepsilon-CTD). The most striking difference in the two structures is an additional carboxy-terminal helix in eIF5. The binding sites of eIF2-beta, eIF3 and eIF1 were mapped onto the structure. eIF2-beta and eIF3 bind to non-overlapping patches of negative and positive electrostatic potential, respectively.

About this Structure

2IU1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5., Bieniossek C, Schutz P, Bumann M, Limacher A, Uson I, Baumann U, J Mol Biol. 2006 Jul 7;360(2):457-65. Epub 2006 May 24. PMID:16781736

Page seeded by OCA on Thu Mar 20 17:33:20 2008

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