4qt6
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the SPRY domain of human HERC1== |
| - | + | <StructureSection load='4qt6' size='340' side='right' caption='[[4qt6]], [[Resolution|resolution]] 1.64Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4qt6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QT6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QT6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARF:FORMAMIDE'>ARF</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qt6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qt6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qt6 PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN]] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
[[Category: Dong, A]] | [[Category: Dong, A]] | ||
| - | [[Category: | + | [[Category: Edwards, A M]] |
| - | + | ||
[[Category: Guan, X]] | [[Category: Guan, X]] | ||
| - | [[Category: | + | [[Category: Hu, J]] |
| + | [[Category: Li, Y]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Tong, Y]] | [[Category: Tong, Y]] | ||
| - | [[Category: | + | [[Category: Wernimont, A]] |
| - | [[Category: | + | [[Category: B30 2]] |
| - | [[Category: | + | [[Category: E3 ubiquitin ligase]] |
| + | [[Category: Herc1]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Spry]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 16:18, 7 January 2015
Crystal structure of the SPRY domain of human HERC1
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Categories: Arrowsmith, C H | Bountra, C | Dong, A | Edwards, A M | Guan, X | Hu, J | Li, Y | Structural genomic | Tong, Y | Wernimont, A | B30 2 | E3 ubiquitin ligase | Herc1 | Sgc | Spry | Transport protein
