4wz3
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the complex between LubX/LegU2/Lpp2887 U-box 1 and Homo sapiens UBE2D2== |
| - | + | <StructureSection load='4wz3' size='340' side='right' caption='[[4wz3]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4wz3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WZ3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wz0|4wz0]], [[4wz1|4wz1]], [[4wz2|4wz2]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wz3 RCSB], [http://www.ebi.ac.uk/pdbsum/4wz3 PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UB2D2_HUMAN UB2D2_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.<ref>PMID:10329681</ref> <ref>PMID:15280377</ref> <ref>PMID:18042044</ref> <ref>PMID:18703417</ref> <ref>PMID:18359941</ref> <ref>PMID:19854139</ref> <ref>PMID:20403326</ref> <ref>PMID:20061386</ref> [[http://www.uniprot.org/uniprot/LUBX_LEGPA LUBX_LEGPA]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ubiquitin--protein ligase]] | ||
[[Category: Joachimiak, A]] | [[Category: Joachimiak, A]] | ||
| + | [[Category: Leo, R Di]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Nocek, B]] | [[Category: Nocek, B]] | ||
| + | [[Category: Quaile, A T]] | ||
[[Category: Savchenko, A]] | [[Category: Savchenko, A]] | ||
| - | [[Category: Yim, V]] | ||
| - | [[Category: Stogios, P.J]] | ||
| - | [[Category: Quaile, A.T]] | ||
[[Category: Skarina, T]] | [[Category: Skarina, T]] | ||
| - | [[Category: | + | [[Category: Stogios, P J]] |
| - | [[Category: | + | [[Category: Yim, V]] |
| + | [[Category: Activating enzyme]] | ||
| + | [[Category: Alpha/beta protein]] | ||
| + | [[Category: Effector]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Mcsg]] | ||
| + | [[Category: Psi-biology]] | ||
Revision as of 16:19, 7 January 2015
Crystal structure of the complex between LubX/LegU2/Lpp2887 U-box 1 and Homo sapiens UBE2D2
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