User:Caroline Cuer/Sandbox 1
From Proteopedia
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| - | == | + | ==ST2/IL33 complex== |
<StructureSection load='4kc3' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='4kc3' size='340' side='right' caption='Caption for this structure' scene=''> | ||
<scene name='61/614056/4kc3/5'>TextToBeDisplayed</scene> | <scene name='61/614056/4kc3/5'>TextToBeDisplayed</scene> | ||
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{{ABSTRACT_PUBMED_23980170}} | {{ABSTRACT_PUBMED_23980170}} | ||
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Lien pour la poche hydrophobe de st2 : <scene name='61/614056/St2_hydrophobic_patch/1'>TextToBeDisplayed</scene> | Lien pour la poche hydrophobe de st2 : <scene name='61/614056/St2_hydrophobic_patch/1'>TextToBeDisplayed</scene> | ||
Lien pour les domaines D1 D2 D3 : <scene name='61/614056/Domains_d1d2d3_de_st2/1'>TextToBeDisplayed</scene> | Lien pour les domaines D1 D2 D3 : <scene name='61/614056/Domains_d1d2d3_de_st2/1'>TextToBeDisplayed</scene> | ||
| - | Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.<ref>PMID:16286016</ref> <ref>PMID:17853410</ref> <ref>PMID:17185418</ref> <ref>PMID:18787100</ref> <ref>PMID:18836528</ref> <ref>PMID:21734074</ref> <ref>PMID:22215666</ref> In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.<ref>PMID:16286016</ref> <ref>PMID:17853410</ref> <ref>PMID:17185418</ref> <ref>PMID:18787100</ref> <ref>PMID:18836528</ref> <ref>PMID:21734074</ref> <ref>PMID:22215666</ref> [[http://www.uniprot.org/uniprot/ILRL1_HUMAN ILRL1_HUMAN]] Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.<ref>PMID:16286016</ref> | ||
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==Reference== | ==Reference== | ||
Revision as of 20:30, 7 January 2015
Contents |
ST2/IL33 complex
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Template:ABSTRACT PUBMED 23980170
Function
[IL33_HUMAN] LIEN VERT POUR FAIRE AFFICHER LE DEGRADE DE COULEUR DE N TER A C TER| N | C |
Lien vert pour afficher les deux protéines :
Lien pour faire apparaitre les trois résidus de ST2 liés chacun à un NAG : Lien pour faire apparaitre le site 1 d'interaction entre ST2 et IL33 : Faire apparaitre les feuillets beta de IL33 : Lien pour faire apparaitre le site 2 d'interaction entre ST2 et IL33 : Lien pour faire apparatire l'hélice alpha de IL33 : Lien pour la poche hydrophobe de st2 : Lien pour les domaines D1 D2 D3 :
Reference
- Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S, Wang X. Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14918-23. doi:, 10.1073/pnas.1308651110. Epub 2013 Aug 26. PMID:23980170 doi:10.1073/pnas.1308651110
