2ius

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[[Image:2ius.jpg|left|200px]]<br /><applet load="2ius" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2ius.jpg|left|200px]]
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caption="2ius, resolution 2.7&Aring;" />
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'''E. COLI FTSK MOTOR DOMAIN'''<br />
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{{Structure
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|PDB= 2ius |SIZE=350|CAPTION= <scene name='initialview01'>2ius</scene>, resolution 2.7&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''E. COLI FTSK MOTOR DOMAIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2IUS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA].
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2IUS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUS OCA].
==Reference==
==Reference==
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Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16916635 16916635]
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Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16916635 16916635]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hexameric ring]]
[[Category: hexameric ring]]
[[Category: inner membrane]]
[[Category: inner membrane]]
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[[Category: kops]]
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[[Category: kop]]
[[Category: membrane]]
[[Category: membrane]]
[[Category: membrane protein]]
[[Category: membrane protein]]
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[[Category: transmembrane]]
[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:56:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:33:43 2008''

Revision as of 15:33, 20 March 2008

Image:2ius.jpg


PDB ID 2ius

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, resolution 2.7Å
Coordinates: save as pdb, mmCIF, xml



E. COLI FTSK MOTOR DOMAIN


Overview

FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers, head to head. Electron microscopy (EM) demonstrates the DNA-dependent existence of hexamers in solution and shows that duplex DNA passes through the middle of each ring. Comparison of FtsK monomer structures from two different crystal forms highlights a conformational change that we propose is the structural basis for a rotary inchworm mechanism of DNA translocation.

About this Structure

2IUS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635

Page seeded by OCA on Thu Mar 20 17:33:43 2008

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