2j05

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[[Image:2j05.jpg|left|200px]]<br /><applet load="2j05" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2j05.jpg|left|200px]]
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caption="2j05, resolution 1.50&Aring;" />
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'''CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION'''<br />
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{{Structure
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|PDB= 2j05 |SIZE=350|CAPTION= <scene name='initialview01'>2j05</scene>, resolution 1.50&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2J05 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J05 OCA].
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2J05 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J05 OCA].
==Reference==
==Reference==
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High resolution crystal structures of the p120 RasGAP SH3 domain., Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M, Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17188236 17188236]
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High resolution crystal structures of the p120 RasGAP SH3 domain., Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M, Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17188236 17188236]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: src homology 3]]
[[Category: src homology 3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:57:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:35:44 2008''

Revision as of 15:35, 20 March 2008

Image:2j05.jpg


PDB ID 2j05

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, resolution 1.50Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION


Contents

Overview

X-ray structures of two crystal forms of the Src homology 3 domain (SH3) of the Ras GTPase activating protein (RasGAP) were determined at 1.5 and 1.8A resolution. The overall structure comprises a single domain with two tightly packed beta-sheets linked by a short helical segment. An important motif for peptide binding in other SH3 domains is not conserved in RasGAP. The RasGAP SH3 domain forms dimers in the crystal structures, which may provide new functional insight. The dimer interface involves residues also present in a peptide previously identified as an apoptotic sensitizer of tumor cells.

Disease

Known diseases associated with this structure: Basal cell carcinoma, somatic OMIM:[139150], Capillary malformation-arteriovenous malformation OMIM:[139150], Parkes Weber syndrome OMIM:[139150]

About this Structure

2J05 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures of the p120 RasGAP SH3 domain., Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M, Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:17188236

Page seeded by OCA on Thu Mar 20 17:35:44 2008

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