2j0a

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[[Image:2j0a.jpg|left|200px]]<br /><applet load="2j0a" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2j0a.jpg|left|200px]]
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caption="2j0a, resolution 1.80&Aring;" />
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'''STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE'''<br />
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{{Structure
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|PDB= 2j0a |SIZE=350|CAPTION= <scene name='initialview01'>2j0a</scene>, resolution 1.80&Aring;
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|SITE= <scene name='pdbsite=AC1:K+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=K:POTASSIUM ION'>K</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/O-fucosylpeptide_3-beta-N-acetylglucosaminyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.222 2.4.1.222]
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|GENE=
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}}
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'''STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2J0A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=K:'>K</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/O-fucosylpeptide_3-beta-N-acetylglucosaminyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.222 2.4.1.222] Known structural/functional Site: <scene name='pdbsite=AC1:K+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0A OCA].
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2J0A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0A OCA].
==Reference==
==Reference==
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Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16964258 16964258]
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Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16964258 16964258]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase]]
[[Category: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase]]
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[[Category: transmembrane]]
[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:57:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:35:49 2008''

Revision as of 15:35, 20 March 2008

Image:2j0a.jpg


PDB ID 2j0a

Drag the structure with the mouse to rotate
, resolution 1.80Å
Sites:
Ligands: and
Activity: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, with EC number 2.4.1.222
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE


Overview

Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify Notch receptors, altering their ligand-binding specificity to regulate Notch signaling in development. We present the crystal structure of mouse Manic Fringe bound to UDP and manganese. The structure reveals amino acid residues involved in recognition of donor substrates and catalysis, and a putative binding pocket for acceptor substrates. Mutations of several invariant residues in this pocket impair Fringe activity in vivo.

About this Structure

2J0A is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:16964258

Page seeded by OCA on Thu Mar 20 17:35:49 2008

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