2j0s

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[[Image:2j0s.gif|left|200px]]<br /><applet load="2j0s" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2j0s.gif|left|200px]]
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caption="2j0s, resolution 2.21&Aring;" />
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'''THE CRYSTAL STRUCTURE OF THE EXON JUNCTION COMPLEX AT 2.2 A RESOLUTION'''<br />
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{{Structure
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|PDB= 2j0s |SIZE=350|CAPTION= <scene name='initialview01'>2j0s</scene>, resolution 2.21&Aring;
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|SITE= <scene name='pdbsite=AC1:Anp+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''THE CRYSTAL STRUCTURE OF THE EXON JUNCTION COMPLEX AT 2.2 A RESOLUTION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2J0S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ANP:'>ANP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Anp+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0S OCA].
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2J0S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0S OCA].
==Reference==
==Reference==
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The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA., Bono F, Ebert J, Lorentzen E, Conti E, Cell. 2006 Aug 25;126(4):713-25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16923391 16923391]
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The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA., Bono F, Ebert J, Lorentzen E, Conti E, Cell. 2006 Aug 25;126(4):713-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16923391 16923391]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: transport]]
[[Category: transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:58:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:36:01 2008''

Revision as of 15:36, 20 March 2008

Image:2j0s.gif


PDB ID 2j0s

Drag the structure with the mouse to rotate
, resolution 2.21Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



THE CRYSTAL STRUCTURE OF THE EXON JUNCTION COMPLEX AT 2.2 A RESOLUTION


Overview

The exon junction complex (EJC) plays a major role in posttranscriptional regulation of mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to the cytoplasm where it influences translation, surveillance, and localization of the spliced mRNA. The complex is formed by the association of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. The 2.2 A resolution structure of the EJC reveals how it stably locks onto mRNA. The DEAD-box protein eIF4AIII encloses an ATP molecule and provides the binding sites for six ribonucleotides. Btz wraps around eIF4AIII and stacks against the 5' nucleotide. An intertwined network of interactions anchors Mago-Y14 and Btz at the interface between the two domains of eIF4AIII, effectively stabilizing the ATP bound state. Comparison with the structure of the eIF4AIII-Btz subcomplex that we have also determined reveals that large conformational changes are required upon EJC assembly and disassembly.

About this Structure

2J0S is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA., Bono F, Ebert J, Lorentzen E, Conti E, Cell. 2006 Aug 25;126(4):713-25. PMID:16923391

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