2j4r

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[[Image:2j4r.gif|left|200px]]<br /><applet load="2j4r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2j4r.gif|left|200px]]
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caption="2j4r, resolution 2.71&Aring;" />
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'''STRUCTURAL STUDY OF THE AQUIFEX AEOLICUS PPX-GPPA ENZYME'''<br />
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{{Structure
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|PDB= 2j4r |SIZE=350|CAPTION= <scene name='initialview01'>2j4r</scene>, resolution 2.71&Aring;
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|SITE= <scene name='pdbsite=AC1:G4p+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=G4P:GUANOSINE-5',3'-TETRAPHOSPHATE'>G4P</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURAL STUDY OF THE AQUIFEX AEOLICUS PPX-GPPA ENZYME'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2J4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] with <scene name='pdbligand=G4P:'>G4P</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:G4p+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4R OCA].
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2J4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4R OCA].
==Reference==
==Reference==
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Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp., Kristensen O, Ross B, Gajhede M, J Mol Biol. 2008 Feb 1;375(5):1469-76. Epub 2007 Dec 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18155044 18155044]
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Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp., Kristensen O, Ross B, Gajhede M, J Mol Biol. 2008 Feb 1;375(5):1469-76. Epub 2007 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18155044 18155044]
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: stringent response]]
[[Category: stringent response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:59:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:37:10 2008''

Revision as of 15:37, 20 March 2008

Image:2j4r.gif


PDB ID 2j4r

Drag the structure with the mouse to rotate
, resolution 2.71Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



STRUCTURAL STUDY OF THE AQUIFEX AEOLICUS PPX-GPPA ENZYME


Overview

The crystal structure of the prototype exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family member from Aquifex aeolicus in complex with the intracellular second messenger guanosine tetraphosphate was determined at 2.7-A resolution. The hydrolytic base is identified as E119. The dual specificity established for the Escherichia coli homolog is shown to be compatible with a common active site for guanosine pentaphosphate and polyphosphate hydrolysis. Distinct and different degrees of closure between the two domains of the enzyme are associated with substrate binding. The arginines R22 and R267, residing in different domains, are crucial for guanosine pentaphosphate specificity as they interact with the unique 3'-ribose phosphorylation.

About this Structure

2J4R is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp., Kristensen O, Ross B, Gajhede M, J Mol Biol. 2008 Feb 1;375(5):1469-76. Epub 2007 Dec 4. PMID:18155044

Page seeded by OCA on Thu Mar 20 17:37:10 2008

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