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2j6o
From Proteopedia
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| - | [[Image:2j6o.gif|left|200px]] | + | [[Image:2j6o.gif|left|200px]] |
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| - | '''ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETEROTRIMER''' | + | {{Structure |
| + | |PDB= 2j6o |SIZE=350|CAPTION= <scene name='initialview01'>2j6o</scene>, resolution 2.225Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETEROTRIMER''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2J6O is a [ | + | 2J6O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J6O OCA]. |
==Reference== | ==Reference== | ||
| - | Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:[http:// | + | Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17020880 17020880] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: Spinola-Amilibia, M.]] | [[Category: Spinola-Amilibia, M.]] | ||
[[Category: adaptor protein]] | [[Category: adaptor protein]] | ||
| - | [[Category: | + | [[Category: cm]] |
[[Category: coiled coil]] | [[Category: coiled coil]] | ||
[[Category: egfr downregulation]] | [[Category: egfr downregulation]] | ||
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[[Category: signaling protein]] | [[Category: signaling protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:37:56 2008'' |
Revision as of 15:37, 20 March 2008
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| , resolution 2.225Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
ATYPICAL POLYPROLINE RECOGNITION BY THE CMS N-TERMINAL SH3 DOMAIN. CMS:CD2 HETEROTRIMER
Overview
The CIN85/CMS (human homologs of mouse SH3KBP1/CD2AP) family of endocytic adaptor proteins has the ability to engage multiple effectors and couple cargo trafficking with the cytoskeleton. CIN85 and CMS (Cas ligand with multiple Src homology 3 (SH3) domains) facilitate the formation of large multiprotein complexes required for an efficient internalization of cell surface receptors. It has recently been shown that c-Cbl/Cbl-b could mediate the formation of a ternary complex between one c-Cbl/Cbl-b molecule and two SH3 domains of CIN85, important for the ability of Cbl to promote epidermal growth factor receptor down-regulation. To further investigate whether multimerization is conserved within the family of adaptor proteins, we have solved the crystal structures of the CMS N-terminal SH3 domain-forming complexes with Cbl-b- and CD2-derived peptides. Together with biochemical evidence, the structures support the notion that, despite clear differences in the interaction surface, both Cbl-b and CD2 can mediate multimerization of N-terminal CMS SH3 domains. Detailed analyses on the interacting surfaces also provide the basis for a differential Cbl-b molecular recognition of CMS and CIN85.
About this Structure
2J6O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain., Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J, J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880
Page seeded by OCA on Thu Mar 20 17:37:56 2008
Categories: Homo sapiens | Protein complex | Bravo, J. | Cardenes, N. | Deribe, Y L. | Dikic, I. | Moncalian, G. | Spinola-Amilibia, M. | Adaptor protein | Cm | Coiled coil | Egfr downregulation | Phosphorylation | Protein binding | Sh3 domain | Sh3 domain recognition | Sh3-binding | Signaling protein
