2b35

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2b35]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B35 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2b35]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B35 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bvr|1bvr]], [[1enz|1enz]], [[1eny|1eny]], [[1zid|1zid]], [[1p44|1p44]], [[1p45|1p45]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bvr|1bvr]], [[1enz|1enz]], [[1eny|1eny]], [[1zid|1zid]], [[1p44|1p44]], [[1p45|1p45]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b35 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b35 RCSB], [http://www.ebi.ac.uk/pdbsum/2b35 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b35 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b35 RCSB], [http://www.ebi.ac.uk/pdbsum/2b35 PDBsum]</span></td></tr>
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<table>
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</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Amin, A.]]
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[[Category: Amin, A]]
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[[Category: Boyne, M S.]]
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[[Category: Boyne, M S]]
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[[Category: Johnson, F.]]
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[[Category: Johnson, F]]
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[[Category: Kaur, T.]]
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[[Category: Kaur, T]]
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[[Category: Novichenok, P.]]
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[[Category: Novichenok, P]]
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[[Category: Stratton, C.]]
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[[Category: Stratton, C]]
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[[Category: Sullivan, T J.]]
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[[Category: Sullivan, T J]]
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[[Category: Truglio, J J.]]
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[[Category: Truglio, J J]]
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[[Category: Zhang, X.]]
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[[Category: Zhang, X]]
[[Category: Enoyl reductase]]
[[Category: Enoyl reductase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]

Revision as of 10:42, 8 January 2015

Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan

2b35, resolution 2.30Å

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