2j9a

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[[Image:2j9a.gif|left|200px]]<br /><applet load="2j9a" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2j9a.gif|left|200px]]
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caption="2j9a, resolution 1.73&Aring;" />
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'''BLLAP IN COMPLEX WITH MICROGININ FR1'''<br />
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{{Structure
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|PDB= 2j9a |SIZE=350|CAPTION= <scene name='initialview01'>2j9a</scene>, resolution 1.73&Aring;
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=AHY:(2S,3R)-3-AMINO-2-HYDROXYDECANOIC+ACID'>AHY</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''BLLAP IN COMPLEX WITH MICROGININ FR1'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2J9A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Microcystis_sp. Microcystis sp.] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=DMS:'>DMS</scene>, <scene name='pdbligand=AHY:'>AHY</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J9A OCA].
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2J9A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Microcystis_sp. Microcystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J9A OCA].
==Reference==
==Reference==
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Binding structure of the leucine aminopeptidase inhibitor microginin FR1., Kraft M, Schleberger C, Weckesser J, Schulz GE, FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17157838 17157838]
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Binding structure of the leucine aminopeptidase inhibitor microginin FR1., Kraft M, Schleberger C, Weckesser J, Schulz GE, FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17157838 17157838]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Microcystis sp.]]
[[Category: Microcystis sp.]]
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[[Category: leucine aminopeptidase]]
[[Category: leucine aminopeptidase]]
[[Category: metal-binding]]
[[Category: metal-binding]]
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[[Category: microcystins]]
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[[Category: microcystin]]
[[Category: microginin]]
[[Category: microginin]]
[[Category: protease]]
[[Category: protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:00:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:38:57 2008''

Revision as of 15:38, 20 March 2008

Image:2j9a.gif


PDB ID 2j9a

Drag the structure with the mouse to rotate
, resolution 1.73Å
Sites:
Ligands: , , , and
Coordinates: save as pdb, mmCIF, xml



BLLAP IN COMPLEX WITH MICROGININ FR1


Overview

Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to inhibit various exopeptidases. The crystal structure of microginin FR1 from Microcystis sp. bound to bovine lens leucine aminopeptidase was established at 1.73 Angstrom resolution. The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors.

About this Structure

2J9A is a Single protein structure of sequence from Bos taurus and Microcystis sp.. Full crystallographic information is available from OCA.

Reference

Binding structure of the leucine aminopeptidase inhibitor microginin FR1., Kraft M, Schleberger C, Weckesser J, Schulz GE, FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:17157838

Page seeded by OCA on Thu Mar 20 17:38:57 2008

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