RiAFP
From Proteopedia
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<StructureSection load='4dt5' size='340' side='right' caption='Insect antifreeze protein complex with sulfate and glycerol (PDB code [[4dt5]]).' scene='60/607864/Chain_a_without_histag/1'> | <StructureSection load='4dt5' size='340' side='right' caption='Insect antifreeze protein complex with sulfate and glycerol (PDB code [[4dt5]]).' scene='60/607864/Chain_a_without_histag/1'> | ||
- | Antifreeze proteins (AFPs) evolved in various organisms permitting their survival in subzero environments<ref>PMID: 11852248</ref>. They exhibit remarkable structural diversity and molar activities across the various kingdoms<ref>10.5772/54992</ref>. The longhorn beetle, Rhagium inquisitor, has the ability to supercool to below -25 °C partially due to the presence of a highly potent AFP (RiAFP) in its hemolymph. RiAFP is a 13-kDa protein with one of the highest antifreeze activities measured for any AFP. | + | Antifreeze proteins (AFPs) evolved in various organisms permitting their survival in subzero environments<ref>PMID: 11852248</ref>. They exhibit remarkable structural diversity and molar activities across the various kingdoms<ref>DOI: 10.5772/54992</ref>. The longhorn beetle, Rhagium inquisitor, has the ability to supercool to below -25 °C partially due to the presence of a highly potent AFP (RiAFP) in its hemolymph. RiAFP is a 13-kDa protein with one of the highest antifreeze activities measured for any AFP. |
== History == | == History == |
Revision as of 19:34, 9 January 2015
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3D structures of antifreeze protein
References
- ↑ Jia Z, Davies PL. Antifreeze proteins: an unusual receptor-ligand interaction. Trends Biochem Sci. 2002 Feb;27(2):101-6. PMID:11852248
- ↑ Chantelle J. Capicciotti, Malay Doshi and Robert N. Ben (2013). Ice Recrystallization Inhibitors: From Biological Antifreezes to Small Molecules, Recent Developments in the Study of Recrystallization, Prof. Peter Wilson (Ed.), ISBN: 978-953-51-0962-4, InTech doi:http://dx.doi.org/10.5772/54992
- ↑ Hakim A, Nguyen JB, Basu K, Zhu DF, Thakral D, Davies PL, Isaacs FJ, Modis Y, Meng W. Crystal structure of an insect antifreeze protein and its implications for ice binding. J Biol Chem. 2013 Apr 26;288(17):12295-304. doi: 10.1074/jbc.M113.450973. Epub, 2013 Mar 12. PMID:23486477 doi:10.1074/jbc.M113.450973