2jdk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2jdk.gif|left|200px]]<br /><applet load="2jdk" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:2jdk.gif|left|200px]]
-
caption="2jdk, resolution 1.10&Aring;" />
+
 
-
'''LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE'''<br />
+
{{Structure
 +
|PDB= 2jdk |SIZE=350|CAPTION= <scene name='initialview01'>2jdk</scene>, resolution 1.10&Aring;
 +
|SITE= <scene name='pdbsite=AC1:T45+Binding+Site+For+Chain+C'>AC1</scene>
 +
|LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
2JDK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=FUC:'>FUC</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:T45+Binding+Site+For+Chain+C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDK OCA].
+
2JDK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JDK OCA].
==Reference==
==Reference==
-
X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives., Marotte K, Sabin C, Preville C, Moume-Pymbock M, Wimmerova M, Mitchell EP, Imberty A, Roy R, ChemMedChem. 2007 Sep 10;2(9):1328-1338. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17623286 17623286]
+
X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives., Marotte K, Sabin C, Preville C, Moume-Pymbock M, Wimmerova M, Mitchell EP, Imberty A, Roy R, ChemMedChem. 2007 Sep 10;2(9):1328-1338. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17623286 17623286]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 30: Line 39:
[[Category: pseudomonas aeruginosa]]
[[Category: pseudomonas aeruginosa]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:02:04 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:40:29 2008''

Revision as of 15:40, 20 March 2008

Image:2jdk.gif


PDB ID 2jdk

Drag the structure with the mouse to rotate
, resolution 1.10Å
Sites:
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE


Overview

Pseudomonas aeruginosa is an opportunistic bacterium showing increasing resistance to antibiotics and consequently represents elevated threatening problems in hospital environments, particularly for cystic fibrosis patients. The use of glycomimetics as an anti-adhesive strategy against microorganisms may complement the use of antibiotics. PA-IIL lectin (LecB) from P. aeruginosa constitutes an appealing target for antibacterial agents, as it has been proposed to play a key role in binding to airway epithelia and/or to be involved in biofilm formation. The lectin has an unusually high affinity for L-fucose and related oligosaccharides. In the work presented herein, the disaccharide alphaFuc1-4GlcNAc is used as a scaffold toward the synthesis of a series of glycomimetic derivatives. Microcalorimetry and structural studies indicate that several of the derivatives are potent inhibitors of the lectin, with affinity in the same range as the best known natural ligand, Lewis a, and could represent interesting leads for the development of future antibacterial compounds.

About this Structure

2JDK is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives., Marotte K, Sabin C, Preville C, Moume-Pymbock M, Wimmerova M, Mitchell EP, Imberty A, Roy R, ChemMedChem. 2007 Sep 10;2(9):1328-1338. PMID:17623286

Page seeded by OCA on Thu Mar 20 17:40:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jdk"
Personal tools