2je1
From Proteopedia
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| - | [[Image:2je1.gif|left|200px]] | + | [[Image:2je1.gif|left|200px]] |
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| - | '''THE CRYSTAL STRUCTURE OF THE TUMOR SUPRESSOR PROTEIN PP32 (ANP32A):STRUCTURAL INSIGHTS INTO THE ANP32 FAMILY OF PROTEINS''' | + | {{Structure |
| + | |PDB= 2je1 |SIZE=350|CAPTION= <scene name='initialview01'>2je1</scene>, resolution 2.69Å | ||
| + | |SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene> | ||
| + | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THE CRYSTAL STRUCTURE OF THE TUMOR SUPRESSOR PROTEIN PP32 (ANP32A):STRUCTURAL INSIGHTS INTO THE ANP32 FAMILY OF PROTEINS''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2JE1 is a [ | + | 2JE1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE1 OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins., Huyton T, Wolberger C, Protein Sci. 2007 Jul;16(7):1308-15. Epub 2007 Jun 13. PMID:[http:// | + | The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins., Huyton T, Wolberger C, Protein Sci. 2007 Jul;16(7):1308-15. Epub 2007 Jun 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17567741 17567741] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: phosphorylation]] | [[Category: phosphorylation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:40:39 2008'' |
Revision as of 15:40, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE CRYSTAL STRUCTURE OF THE TUMOR SUPRESSOR PROTEIN PP32 (ANP32A):STRUCTURAL INSIGHTS INTO THE ANP32 FAMILY OF PROTEINS
Overview
The tumor suppressor protein pp32 is highly overexpressed in many cancers of the breast and prostate, and has also been implicated in the neurodegenerative disease spinocerebellar ataxias type 1 (SCA1). Pp32 is a multifunctional protein that is involved in the regulation of transcription, apoptosis, phosphorylation, and cell cycle progression, the latter through its association with the hyperphosphorylated form of the retinoblastoma tumor suppressor. We have determined the structure of an N-terminal pp32 fragment comprising a capped leucine-rich repeat (LRR) domain, which provides insight into the structural and biochemical properties of the pp32 (Anp32) family of proteins.
About this Structure
2JE1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins., Huyton T, Wolberger C, Protein Sci. 2007 Jul;16(7):1308-15. Epub 2007 Jun 13. PMID:17567741
Page seeded by OCA on Thu Mar 20 17:40:39 2008
Categories: Homo sapiens | Single protein | Huyton, T. | Wolberger, C. | GOL | Anp32 | Lanp | Leucine-rich repeat | Lrr | Nuclear protein | Phapi | Phosphorylation
