4co7
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Crystal structure of human GATE-16== |
| - | + | <StructureSection load='4co7' size='340' side='right' caption='[[4co7]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4co7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CO7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4co7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4co7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4co7 RCSB], [http://www.ebi.ac.uk/pdbsum/4co7 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/GBRL2_HUMAN GBRL2_HUMAN]] Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.<ref>PMID:20418806</ref> <ref>PMID:23209295</ref> |
| - | [ | + | == References == |
| - | [[ | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ma, P]] | [[Category: Ma, P]] | ||
| + | [[Category: Weiergraeber, O H]] | ||
| + | [[Category: Willbold, D]] | ||
| + | [[Category: Autophagy]] | ||
| + | [[Category: Beta-grasp fold]] | ||
| + | [[Category: Protein transport]] | ||
| + | [[Category: Ubiquitin superfamily]] | ||
Revision as of 13:38, 14 January 2015
Crystal structure of human GATE-16
| |||||||||||
