4oeo

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'''Unreleased structure'''
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==High resolution crystal structure of the unliganded ZO-1 PDZ1 domain==
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<StructureSection load='4oeo' size='340' side='right' caption='[[4oeo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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The entry 4oeo is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4oeo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OEO FirstGlance]. <br>
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Authors: Nomme, J., Lavie, A.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oep|4oep]], [[4oeq|4oeq]]</td></tr>
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Description: High resolution crystal structure of the unliganded ZO-1 PDZ1 domain
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oeo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oeo RCSB], [http://www.ebi.ac.uk/pdbsum/4oeo PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Lavie, A]]
[[Category: Lavie, A]]
[[Category: Nomme, J]]
[[Category: Nomme, J]]
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[[Category: Cell adhesion]]
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[[Category: Claudin]]
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[[Category: Maguk]]
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[[Category: Pdz1]]
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[[Category: Scaffolding]]
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[[Category: Tight junction assembly]]

Revision as of 13:42, 14 January 2015

High resolution crystal structure of the unliganded ZO-1 PDZ1 domain

4oeo, resolution 1.90Å

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