4oep
From Proteopedia
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| - | ''' | + | ==Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail== |
| - | + | <StructureSection load='4oep' size='340' side='right' caption='[[4oep]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4oep]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OEP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oeo|4oeo]], [[4oeq|4oeq]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oep RCSB], [http://www.ebi.ac.uk/pdbsum/4oep PDBsum]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Lavie, A]] | [[Category: Lavie, A]] | ||
[[Category: Nomme, J]] | [[Category: Nomme, J]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Claudin]] | ||
| + | [[Category: Maguk]] | ||
| + | [[Category: Pdz1]] | ||
| + | [[Category: Scaffolding]] | ||
| + | [[Category: Tight junction assembly]] | ||
Revision as of 13:42, 14 January 2015
Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail
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Categories: Lavie, A | Nomme, J | Cell adhesion | Claudin | Maguk | Pdz1 | Scaffolding | Tight junction assembly
