4r08
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of human TLR8 in complex with ssRNA40== |
| - | + | <StructureSection load='4r08' size='340' side='right' caption='[[4r08]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4r08]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R08 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UCG:3-O-[(R)-{[(2R,3AR,4R,6R,6AR)-6-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-2-HYDROXY-2-OXIDOTETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-4-YL]METHOXY}(HYDROXY)PHOSPHORYL]URIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UCG</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r07|4r07]], [[4r09|4r09]], [[4r0a|4r0a]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r08 RCSB], [http://www.ebi.ac.uk/pdbsum/4r08 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ohto, U]] | [[Category: Ohto, U]] | ||
[[Category: Shimizu, T]] | [[Category: Shimizu, T]] | ||
| + | [[Category: Tanji, H]] | ||
| + | [[Category: Antitumor drug binding]] | ||
| + | [[Category: Antiviral binding]] | ||
| + | [[Category: Glycosylation]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Innate immunity]] | ||
| + | [[Category: Leucine rich repeat]] | ||
| + | [[Category: Rna binding]] | ||
| + | [[Category: Rna receptor]] | ||
| + | [[Category: Rna recognition]] | ||
Revision as of 13:43, 14 January 2015
Crystal structure of human TLR8 in complex with ssRNA40
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