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4wnv
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Human Cytochrome P450 2D6 Quinine Complex== |
| - | + | <StructureSection load='4wnv' size='340' side='right' caption='[[4wnv]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4wnv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WNV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=QI9:QUININE'>QI9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tbg|3tbg]], [[3tda|3tda]], [[3qm4|3qm4]], [[2f9q|2f9q]], [[4wnw|4wnw]], [[4wnu|4wnu]], [[4wnt|4wnt]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wnv RCSB], [http://www.ebi.ac.uk/pdbsum/4wnv PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN]] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Unspecific monooxygenase]] | ||
| + | [[Category: Johnson, E F]] | ||
| + | [[Category: Stout, C D]] | ||
[[Category: Wang, A]] | [[Category: Wang, A]] | ||
| - | [[Category: | + | [[Category: Cyp2d6]] |
| - | [[Category: | + | [[Category: Monooxygenase]] |
| + | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
| + | [[Category: P450]] | ||
| + | [[Category: P450 2d6]] | ||
Revision as of 13:48, 14 January 2015
Human Cytochrome P450 2D6 Quinine Complex
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