4wpf

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'''Unreleased structure'''
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==Crystal structure of RORc in complex with a phenyl sulfonamide agonist==
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<StructureSection load='4wpf' size='340' side='right' caption='[[4wpf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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The entry 4wpf is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4wpf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WPF FirstGlance]. <br>
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Authors: Kiefer, J.R., Wallweber, H.A., Boenig, G., Hymowitz, S.G.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SN:N-[4-(4-ACETYLPIPERAZIN-1-YL)-2-FLUOROBENZYL]-N-CYCLOBUTYLBENZENESULFONAMIDE'>3SN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wpf RCSB], [http://www.ebi.ac.uk/pdbsum/4wpf PDBsum]</span></td></tr>
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Description:
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Hymowitz, S.G]]
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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__TOC__
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</StructureSection>
[[Category: Boenig, G]]
[[Category: Boenig, G]]
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[[Category: Kiefer, J.R]]
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[[Category: Hymowitz, S G]]
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[[Category: Wallweber, H.A]]
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[[Category: Kiefer, J R]]
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[[Category: Wallweber, H A]]
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[[Category: Nuclear receptor]]
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[[Category: Ror]]
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[[Category: Rorc]]
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[[Category: Rorg]]
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[[Category: Transcription]]

Revision as of 13:48, 14 January 2015

Crystal structure of RORc in complex with a phenyl sulfonamide agonist

4wpf, resolution 2.20Å

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