2jhb
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2jhb.jpg|left|200px]] | + | [[Image:2jhb.jpg|left|200px]] |
| - | + | ||
| - | '''CORE BINDING FACTOR BETA''' | + | {{Structure |
| + | |PDB= 2jhb |SIZE=350|CAPTION= <scene name='initialview01'>2jhb</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CBFB141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''CORE BINDING FACTOR BETA''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2JHB is a [ | + | 2JHB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHB OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of core binding factor beta and map of the CBF alpha binding site., Huang X, Peng JW, Speck NA, Bushweller JH, Nat Struct Biol. 1999 Jul;6(7):624-7. PMID:[http:// | + | Solution structure of core binding factor beta and map of the CBF alpha binding site., Huang X, Peng JW, Speck NA, Bushweller JH, Nat Struct Biol. 1999 Jul;6(7):624-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10404216 10404216] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 20: | Line 29: | ||
[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:41:56 2008'' |
Revision as of 15:41, 20 March 2008
| |||||||
| Gene: | CBFB141 (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CORE BINDING FACTOR BETA
Overview
The core binding factor beta subunit (CBF beta) is the non-DNA binding subunit of the core-binding factors, transcription factors essential for multiple developmental processes including hematopoiesis and bone development. Chromosomal translocations involving the human CBFB gene are associated with a large percentage of human leukemias. The N-terminal 141 amino acids of CBF beta contains the heterodimerization domain for the DNA-binding CBF alpha subunits, and is sufficient for CBF beta function in vivo. Here we present the high-resolution solution structure of the CBF beta heterodimerization domain. It is a novel alpha/beta structure consisting of two three-stranded beta-sheets packed on one another in a sandwich arrangement, with four peripheral alpha-helices. The CBF alpha binding site on CBF beta has been mapped by chemical shift perturbation analysis.
About this Structure
2JHB is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Solution structure of core binding factor beta and map of the CBF alpha binding site., Huang X, Peng JW, Speck NA, Bushweller JH, Nat Struct Biol. 1999 Jul;6(7):624-7. PMID:10404216
Page seeded by OCA on Thu Mar 20 17:41:56 2008
