2dll
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dll]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DLL FirstGlance]. <br> | <table><tr><td colspan='2'>[[2dll]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DLL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IRF4, MUM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IRF4, MUM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dll RCSB], [http://www.ebi.ac.uk/pdbsum/2dll PDBsum], [http://www.topsan.org/Proteins/RSGI/2dll TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dll RCSB], [http://www.ebi.ac.uk/pdbsum/2dll PDBsum], [http://www.topsan.org/Proteins/RSGI/2dll TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/IRF4_HUMAN IRF4_HUMAN]] Defects in IRF4 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IRF4 is found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus. | [[http://www.uniprot.org/uniprot/IRF4_HUMAN IRF4_HUMAN]] Defects in IRF4 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IRF4 is found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus. | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Hayashi, F | + | [[Category: Hayashi, F]] |
| - | [[Category: Kurosaki, C | + | [[Category: Kurosaki, C]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
| - | [[Category: Yoshida, M | + | [[Category: Yoshida, M]] |
| - | [[Category: Zhang, H P | + | [[Category: Zhang, H P]] |
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Interferon regulatory factor 4]] | [[Category: Interferon regulatory factor 4]] | ||
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[[Category: Nf-em5]] | [[Category: Nf-em5]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
| - | [[Category: Structural genomic]] | ||
Revision as of 16:44, 15 January 2015
Solution structure of the IRF domain of human interferon regulator factors 4
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Categories: Homo sapiens | Hayashi, F | Kurosaki, C | Structural genomic | Yokoyama, S | Yoshida, M | Zhang, H P | Cytokine | Interferon regulatory factor 4 | Irf domain | Lymphocyte specific interferon regulatory factor | Multiple myeloma oncogene 1 | National project on protein structural and functional analyse | Nf-em5 | Nppsfa | Rsgi
