2jm6

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[[Image:2jm6.gif|left|200px]]<br /><applet load="2jm6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2jm6.gif|left|200px]]
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caption="2jm6" />
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'''Solution structure of MCL-1 complexed with NOXAB'''<br />
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{{Structure
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|PDB= 2jm6 |SIZE=350|CAPTION= <scene name='initialview01'>2jm6</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= Pmaip1, Noxa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Mcl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''Solution structure of MCL-1 complexed with NOXAB'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2JM6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA].
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2JM6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA].
==Reference==
==Reference==
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Structural insights into the degradation of Mcl-1 induced by BH3 domains., Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17389404 17389404]
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Structural insights into the degradation of Mcl-1 induced by BH3 domains., Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17389404 17389404]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: mcl-1]]
[[Category: mcl-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:03:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:42:44 2008''

Revision as of 15:42, 20 March 2008

Image:2jm6.gif


PDB ID 2jm6

Drag the structure with the mouse to rotate
Gene: Pmaip1, Noxa (Mus musculus), Mcl1 (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



Solution structure of MCL-1 complexed with NOXAB


Overview

Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.

About this Structure

2JM6 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural insights into the degradation of Mcl-1 induced by BH3 domains., Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:17389404

Page seeded by OCA on Thu Mar 20 17:42:44 2008

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