2jnr
From Proteopedia
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| - | [[Image:2jnr.jpg|left|200px]] | + | [[Image:2jnr.jpg|left|200px]] |
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| - | '''Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide''' | + | {{Structure |
| + | |PDB= 2jnr |SIZE=350|CAPTION= <scene name='initialview01'>2jnr</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2JNR is a [ | + | 2JNR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNR OCA]. |
==Reference== | ==Reference== | ||
| - | Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide., Munch J, Standker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pohlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F, Cell. 2007 Apr 20;129(2):263-75. PMID:[http:// | + | Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide., Munch J, Standker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pohlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F, Cell. 2007 Apr 20;129(2):263-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17448989 17448989] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Adermann, K.]] | [[Category: Adermann, K.]] | ||
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[[Category: peptide complex]] | [[Category: peptide complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:43:16 2008'' |
Revision as of 15:43, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide
Overview
A variety of molecules in human blood have been implicated in the inhibition of HIV-1. However, it remained elusive which circulating natural compounds are most effective in controlling viral replication in vivo. To identify natural HIV-1 inhibitors we screened a comprehensive peptide library generated from human hemofiltrate. The most potent fraction contained a 20-residue peptide, designated VIRUS-INHIBITORY PEPTIDE (VIRIP), corresponding to the C-proximal region of alpha1-antitrypsin, the most abundant circulating serine protease inhibitor. We found that VIRIP inhibits a wide variety of HIV-1 strains including those resistant to current antiretroviral drugs. Further analysis demonstrated that VIRIP blocks HIV-1 entry by interacting with the gp41 fusion peptide and showed that a few amino acid changes increase its antiretroviral potency by two orders of magnitude. Thus, as a highly specific natural inhibitor of the HIV-1 gp41 fusion peptide, VIRIP may lead to the development of another class of antiretroviral drugs.
About this Structure
2JNR is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide., Munch J, Standker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pohlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F, Cell. 2007 Apr 20;129(2):263-75. PMID:17448989
Page seeded by OCA on Thu Mar 20 17:43:16 2008
Categories: Single protein | Adermann, K. | Biet, T. | Chaipan, C. | Forssmann, W. | Jiang, S. | Jing, W. | Kirchhoff, F. | Lu, H. | Meyer, B. | Munch, J. | Peters, T. | Pohlmann, S. | Schulz, A. | Standker, L. | Wilhelm, D. | Peptide complex
